Bugs, babies and bumps

Moms , babies , and bugs in immune development

Bacteria and mammals have co-evolved with one another over millennia, and it has become impossible to interpret mucosal immunity without taking the microbiota into consideration. In fact, the primary role of the mucosal immune system is regulating homeostasis and the host relationship with the microbiota. Bacteria are no longer seen as simply invading pathogens, but rather a necessary component...

First Opinion: Babies, Babies, and More Babies

Smoothings, Ridges, and Bumps

In this paper, we seek to formulate a geometrically based alternative to nonlinear, nonparametric regression. Hastie and Stuetzle (1989) introduced the ideas of principal curves and surfaces. These were 1and 2-dimensional non-linear regression-type estimators, which were consistent with respect to the mean, i.e. involved conditional expectations. We have developed a similar notion, but with two...

Steps and bumps

We report new statistical time-series analysis tools providing significant improvements in the rapid, precision extraction of discrete state dynamics from large databases of experimental observations of molecular machines. By building physical knowledge and statistical innovations into analysis tools, we demonstrate new techniques for recovering discrete state transitions buried in highly corre...

Lumps, bumps and diagnostic stumps.

British Journal of General Practice, December 2013 663 IntroduCtIon Numquam ponenda est pluralitas sine necessitate (plurality ought never be posed without necessity), proposed William of Ockham (Occam) in the early 14th century. Commonly known as ‘Occam’s razor’, this principle asserts that a single unifying diagnosis is more likely to explain multiple simultaneous presenting symptoms than sev...